Endocrine Abstracts

Introduction: It is evident that hypothyroid patients have higher BMI than euthyroids. Until recently, much attention has been focused on finding whether minor abnormalities of thyroid function or differences in thyroid status of euthyroid subjects are related to body weight. Controversies, however, exist regarding the role of TSH in weight changes of euthyroid subjects.Objective: The aim of this study, the Tehran Thyroid Study, was to determine any poss...

Previous observational studies suggest that low 25(OH)D concentrations in childhoodmight have deleterious effects on vasculature. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed to determine the effect ofone-year vitamin D supplementationon carotid intima media thickness (cIMT) in overweight and obese school children. The current study was a single-blind RCT. A total of 378 children and adolescents, 6&#82...

Introduction: Trials on children and adolescents with excess weight are limited and lack parathyroid hormone (PTH) measures as a surrogate marker of vitaminD status in skeletal health. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed at determining vitamin D requirement to increase 25(OH)D and suppress PTH concentrations in overweight and obese school children.Methods: The current st...

Background and aim: The 25OHD concentration at which intact parathyroid hormone (iPTH) is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25OHD concentration. While it is not known if the lower 25OHD levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children, we aimed to study the relation between circulating PTH and 25OHD levels and to search for a 25OHD threshold...